Botanicals have long been an important part of the treatment of chronic and infected wounds, even if modern science still has a limited knowledge of the molecular basis of these medications. Diuretics are drugs that increase the flow of urine and salt excretion. They are employed in a variety of therapeutic conditions to change the volume and content of body fluids. In clinical practice, most complete diuretics are used to reduce extracellular fluid volume by lowering total body NaCl levels. Electrolyte imbalance and metabolic alterations are common adverse effects of today's diuretics, such as thiazides and loop diuretics. Tecoma stans (L.) Juss. ex Kunth (Bignoniaceae) is an attractive evergreen plant known as kusi urakame, koyawari, Palo amarillo, tronadora, yellow-elder, yellow trumpet bush, trumpet-flower, yellow-bells, trumpet bush, ginger-Thomas, esperanza, and timboco. It is widely used in traditional Mexican medicine, to treat hyperglycemia, gastrointestinal and urinary tract disorders, jaundice, toothaches, headaches, colds, skin infections, and scorpion, snake, and rat bites. Current research focusses on evaluating its bioactive components and therapeutic potential. Tecoma stans confirmed its origin, ethnopharmacological and therapeutic uses. Method: In the current study, a molecular docking technique was used to try and identify UT-1 protein inhibitors. A grid-based docking strategy was used to determine the binding using the Auto Dock software. Result:TS leaf found to be effective diuretic agent and their lead molecules effectively binds to be target protein UT-1 enzyme with binding energy -3.06 & -3.54 kcalmol-1 for chlorogenic acid & caffeic acid respectively. Conclusion: A computationally based docking investigation revealed that both lead compound (chlorogenic acid and caffeic acid) has potent UT-1 inhibitory properties