The main aim of this work is to focus on requirement of knowledge and research work in metabolism by health care workers in restoration of a patient’s health. Metabolism, a process drives physiological functions of a cell and life.Alterations in this process, generates metabolic disturbances,effects immune system functionality and leads to diseases, like cancer, type 2 diabetes, gut dysbiosis,neurological problems, etc. Survival of a cell and performing its physiological functions under such condition is called as metabolic reprogramming.This diseased condition can modulate metabolic flux, and it is necessary to understand the process behind.