This study examined the effects of palmatine, on neurotoxicity induced by aluminum chloride in rats. The rats were administered with palmatine orally at doses of 10 and 20 mg/kg for 42 days alongside aluminum chloride to induce neurotoxicity. Oxidative stress marker measurements, brain levels of aluminum, and immunohistochemistry for determining the expression of BDNF and beta- amyloid plaques were performed. Palmatine treatment significantly improved cognitive function and behavior, reduced oxidative stress markers, decreased brain aluminum levels, inhibited β- Amyloid expression, and reduced neuronal damage and apoptosis. The study's findings suggest that palmatine has therapeutic potential against aluminum-induced neurotoxicity, highlighting its relevance for Aluminium induced neurodegeneration and Alzheimer's disease. Further investigations are necessary to inspect the underlying mechanisms and their translational potential in Alzheimer's disease treatment.