This study investigates the formulation of multiparticulate systems aimed at improving the delivery of diacerein, a potent agent in osteoarthritis (OA) treatment, utilizing Eudragit beads via extrusion spheronization. The study addresses key challenges associated with diacerein through systematic polymer selection, formulation optimization, and comprehensive characterization, including its poor solubility, variable absorption, and gastrointestinal side effects. By employing innovative sieving/spheronization techniques, the study achieves significant reductions in material wastage, enhances formulation yield, and ensures the production of uniform, spherical pellets with superior drug release properties. Optimization strategies facilitated by DesignExpert® software lead to the identification of formulation parameters conducive to achieving desired drug release kinetics and mechanical characteristics. The successful scaling up of the optimized batch confirms the effectiveness of the approach, underlining the potential of multiparticulate systems as a promising avenue for optimizing diacerein delivery in OA therapy. Further investigations may focus on refining formulations and conducting preclinical efficacy evaluations to fully elucidate the therapeutic benefits of multiparticulate systems in OA management.