Biosensors are a diverse category of sensors and can be differentiated not only by their mechanical components but by the biological sensing unit they utilize and several other specialization mechanisms, most orally administered drug that are soluble in water and capable of penetrating biological membrane during the passage of gastrointestinal tract will eventually become bioavailable in the body, due to low solubility in the drug. Comprehensive knowledge of the pathogenesis of vascular aging may lead to the identification of new biomarkers and therapeutic targets, providing new insights toward future vascular aging treatment. The advancement in nanotechnology has resulted in an amazing revolution in the diagnosis and treatment of vascular aging-related diseases.