Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor impairments, including tremors, rigidity, and bradykinesia. Additionally, cognitive deficits and neuropsychiatric symptoms often accompany the motor symptoms, contributing to the overall burden of the disease. The deposition of alpha-synuclein aggregates, known as Lewy bodies, in dopaminergic neurons of the substantia nigra is a pathological hallmark of Parkinson's disease. The present study aimed to investigate the potential therapeutic effects of hydroalcoholic extract of Ipomoea aquatica (HAEIA) in a mouse model of Parkinson's disease induced by neurotoxic agents such as 6-hydroxydopamine (6-OHDA) or MPTP. Animals received HAEIA treatment for a specified duration. Behavioral assessments, including rotarod test, pole test, and open field test, were conducted to evaluate motor function and exploratory behavior. Results from the study demonstrated that HAEIA treatment attenuated motor deficits induced by neurotoxic agents and exerted neuroprotective effects by modulating oxidative stress and neuroinflammation in the brain. These findings suggest that HAEIA may hold promise as a potential therapeutic agent for the management of Parkinson's disease.