Laparoscopic cholecystectomy (LC) being the gold standard in the treatment of cholelithiasis, with raising incidence in India, associated with increase in the number of difficult LC. This study is conducted to predict difficult LC pre-operatively which can help the patient as well as the surgeon prepare better for the intra-operative risk and the risk of conversion to open cholecystectomy. Methods: A one and half year (November 2018 to April 2020) prospective observational study was conducted on 50 patients who underwent LC in the Department of General Surgery at Dr. B. R. AMCH, who’s clinical, sonological and operative details were analysed. Results: Of the total participants (n=50), 13 (26%) were males and 37 (74%) were females, showing higher incidence in females. Majority of the participants belonged to 31 – 40 years age group (28%). Obesity showed strong co-relation between BMI >30 kg/m2 and difficult surgery. USG parameters had significant correlation with prediction of difficult LC i.e., Contracted GB (n=9) had significant correlation with gall bladder bed dissection (p= 0.002) and difficult GB extraction (p=0.014). Thickened GB wall showed good correlation with moderate bleeding during surgery (p < 0.001), GB bed dissection (p=0.031). Multiple calculi had an evident correlation with difficult bed dissection (p=0.04). Impacted stone (n=5) also had a moderate correlation with bleeding during surgery (p=0.042). Stone size greater than 1 cm (n= 20) was significantly associated with difficulty in extraction of gall bladder (p<0.001). 5 patients had deranged LFT, out of these 2 had difficult surgery due to bleeding, but the data was not statistically significant Conclusion: From our study we conclude that the obesity and sonological parameters like thickened gall bladder wall, contracted gall bladder, stone size >1 cm and to some extent multiple stones and immobile/impacted gall stones were significantly correlated with difficult laparoscopic cholecystectomy