This comprehensive study focused on the fabrication, development and evaluation of six mucoadhesive gastroretentive formulations (CVF-1 to CVF-6) through various critical parameters, including encapsulation efficiency, drug loading capacity, mucoadhesion, yield percentage, swelling index, and kinetic modelling of drug release. The encapsulation efficiency revealed CVF-6 as the most effective, with a high percentage suggesting minimal drug loss during the encapsulation process. The drug loading capacity was notably high for CVF-4, indicating its potential for delivering a substantial amount of drug per unit weight of the microsphere. Furthermore, mucoadhesive properties and in vitro drug release studies at pH 1.2 provided insights into the interaction of microspheres with the gastric mucosa and their subsequent drug release behaviours. Kinetic modelling using Zero-order, First-order, Higuchi, and Korsmeyer-Peppas models validated the drug release mechanisms, highlighting the formulations' capacity for sustained and controlled drug release, particularly for CVF-2 and CVF-6 which demonstrated superior comprehensive profiles as gastroretentive mucoadhesive microspheres.