This study explores the development and evaluation of a floating gastroretentive drug delivery system (GRDDS) utilizing a hydroxypropyl methylcellulose (HPMC) matrix and sodium bicarbonate as a gas-generating agent to sustain the release of bisoprolol over a 24-hour period. The objective was to formulate a floating tablet that initiates floating within 15 minutes and maintains a consistent drug release through hydrodynamic balance. The drug release profile was segmented into various phases: an initial burst in the first hour, followed by a steady release phase extending up to 8 hours, and concluding with a tailing off phase up to 12 hours, eventually leading to complete dissolution by 24 hours. The release kinetics were analysed, assuming near zero-order kinetics, indicative of a controlled release mechanism. The influence of polymer concentration on the release rate was significant, as increased HPMC content slowed the release, providing a denser gel barrier, while higher levels of sodium bicarbonate enhanced the buoyancy and modified release dynamics by increasing the surface area exposed to gastric fluids. This research underscores the potential of floating GRDDS of bisoprolol in improving the bioavailability and efficacy of drugs requiring prolonged gastric retention. The study provides a foundational understanding for optimizing drug release profiles of bisoprolol in floating tablet formulations.