Organogenesis in vertebrates is a highly orchestrated process involving intricate genetic networks and morphogen gradients that govern tissue patterning and organ development. Zebrafish (Danio rerio) embryos have emerged as a powerful model system for investigating these fundamental processes due to their optical transparency, rapid external development, and genetic tractability. This paper provides a comprehensive overview of the genetic mechanisms and morphogenetic principles underlying organogenesis in zebrafish embryos, with broader implications for vertebrate development. Key genetic networks drive tissue patterning during organogenesis. Transcription factors play pivotal roles in specifying cell fate and establishing spatial domains within developing tissues. Signaling pathways, such as Wnt, Notch, and FGF, mediate communication between cells and coordinate diverse cellular behaviors essential for organ formation. Interactions between these genetic regulators orchestrate precise spatiotemporal patterns of gene expression, ultimately shaping the complex architecture of vertebrate organs. Morphogen gradients play a central role in tissue patterning by providing positional information to cells. Zebrafish studies have elucidated the roles of morphogens like Sonic hedgehog (Shh), Bone morphogenetic proteins (BMPs), and Fibroblast growth factors (FGFs) in establishing gradients that guide organogenesis. Mechanisms of gradient formation and interpretation are essential for understanding how cells interpret positional cues to adopt specific fates and organize into functional tissues and organs.