Aim: Stevens-Johnson syndrome (SJS) and TEN both mucocutaneous diseases are caused by some drug reactions. Their clinical appearance differs based on the extent of the lesion involving the skin surface area. The aim of this study is to assess the various drugs and other triggering factors with an evaluation of sites involved in oral and maxillofacial region in patients of SJS/ TEN. Methods: We enrolled 30 patients who were diagnosed with SJS/ TEN, which were assessed in terms of changes involving the oral and maxillofacial region and the correlation of different predisposing triggering factors. Results: In both diseases, the most common prodromal symptoms were itching, fever, and malaise. The mucosal membrane of the oral cavity and eyes were seen to be affected. The most common causative agents in both diseases were antibiotics, allopurinol, anticonvulsants, NSAIDs and others including the patients were positive for HIV /tuberculosis. Conclusions: Anticonvulsants were reported to be the second most common factor, after antibiotics, in the development of oral and maxillofacial alterations in patients with SJS and TEN, and this could be explained by the increase in anticonvulsants usage these days in our country. While some percentage of drugs like NSAIDS, allopurinol, and some ayurvedic medicines were found to be present in causing lesions in the maxillofacial region.