Type 2 diabetes mellitus (T2DM) is a global health concern associated with systemic as well as oral complications. The preventive antioxidants found in saliva naturally reduce the damaging effects of reactive oxygen molecules. Any disruption to the regular functioning of these antioxidants may lead to oxidative stress, which could boost an individual's vulnerability to oral diseases. Diabetes patients are vulnerable to various dental complications, such as oral mucosal disorders, dental caries, dry mouth, and periodontal disease. Objectives: To assess the salivary Hydrogen peroxide (H2O2) and Nitric oxide (NO) levels in patients with controlled and uncontrolled type 2 diabetes mellitus. Materials and methods: The present study included 40 samples aged 45-65 years. Group I consisted of 20 controlled diabetic patients, and Group II consisted of 20 uncontrolled diabetic patients. Unstimulated whole saliva samples were collected from both groups, and laboratory analysis was done. Salivary Hydrogen peroxide (H2O2) and Nitric oxide (NO) levels were quantified using an Enzyme-Linked Immunosorbent Assay (ELISA) and Spectrophotometric assay. Results: Salivary Hydrogen peroxide levels were found to be higher in the uncontrolled diabetic group than in the controlled diabetic group, and salivary NO levels were found to be higher in the controlled diabetic group than in the uncontrolled diabetic group. The Mean±SD values of Hydrogen peroxide among controlled and uncontrolled diabetic patients are 2.98±0.12 and 2.99±0.11, respectively. The mean±SD value of NO in the controlled group was found to be 2.99±0.15, and in the unchecked group, it had a mean±SD value of NO as 2.64±0.96. However, it has been found that there is no statistically significant difference between Hydrogen peroxide and NO levels among controlled and uncontrolled diabetics, with p-values of 0.867 and 0.419, respectively. Conclusion: Values of salivary biochemical markers were distinctly different between controlled and uncontrolled diabetic groups, suggesting the usefulness of salivary Hydrogen peroxide (H2O2) and Nitric oxide (NO) levels in Type 2 diabetics.