Pain is a multidimensional experience that affects a large part of the world’s population. This effect is greater on women, the elderly, rural residents, and socioeconomically disadvantaged groups. Considering the progress of medical and dental sciences, pain management is considered as a complex experience both biologically and psychologically. Hence it remains a challenge that has not been fully resolved. This article researches about various methods of pain management, including physiotherapy, psychological management, pharmacological approaches include NSAIDs, opioids, anticonvulsants, and etc., each targeting various pain mechanisms. In addition, developments in nanotechnology and artificial intelligence is included too. It should be noted that challenges including addiction and side effects of drugs still exist and the need for innovation in this field is evident. Among the important findings are the integrated approaches that are a combination of drug, physiotherapy, and psychological treatments that lead to comprehensive pain management. This research combines the findings of relevant studies and emphasizes the importance of a multifaceted approach to pain management. It is necessary that future research focuses on optimizing integrated approaches and increasing patient education in order to improve the quality of self-care in the target population, and better pain management outcomes.