Tuberculosis (TB) remains a significant global health challenge, with substantial morbidity and mortality rates. Effective TB management relies on prolonged, consistent treatment with multiple antibiotics, posing challenges for patient adherence and the emergence of drug resistance. Fixed drug combinations (FDCs) have emerged as a promising approach to streamline TB treatment regimens. This study aimed to evaluate the pattern of FDC and polytherapy prescriptions in TB patients in Delhi and the National Capital Region (NCR). A prospective observational study was conducted over two years and six months at a tertiary care facility in Haryana. Data were collected from 107 TB patients prescribed FDCs. Results showed that the majority of patients were aged between 19 to 40 years (42.99%), with a relatively equal distribution between males (52.34%) and females (47.66%). Among the participants, 38.32% were prescribed two sets of FDC drugs, while 22.43% received three sets. Notably, 56.66% of patients were on polytherapy. In conclusion, while FDCs hold promise for improving TB treatment adherence and outcomes, ongoing research and concerted efforts are essential to address challenges related to pharmacokinetic interactions, global implementation, and polytherapy. Collaborative action among stakeholders is imperative to optimize FDC utilization and effectively manage TB on a global scale.