Periodontitis is the most common disease entity affecting oral cavity next to dental caries. In the earliest stage the infection affects the gums and as the disease progress, the supporting structures of the tooth are affected. Periodontitis starts due to Gram-negative bacteria on teeth forming a biofilm and leading to an immune response from the body. “Perioceutics” or use of the pharmacological agents to specifically manage periodontitis is an interesting and emerging aids in the development of periodontal disease along with the mechanical debridement. Compared to other therapeutic modalities employed against infection, perioceutics potentially is non-invasive, has fewer side-effects and does not require complicated application method. This paper review ‘Perioceutics’ which in future will be the effective tool for dental practitioners when used as adjunct to mechanical therapy in treating periodontal diseases.