ISSN : 2663-2187

Peripheral neuropathy in children and adolescent with Inflammatory Bowel diseases

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Amr Ibrahim Risha, Mohammed Hammed, Enas Abdelhady, Diana Hanna Abdelmalek Hanna, Yasmeen Hassan
» doi: 10.33472/AFJBS.6.2.2024.248-253

Abstract

The inflammatory bowel diseases (IBDs), which are primarily represented by Crohn's disease (CD) and ulcerative colitis (UC), are immune dysregulation-related chronic, relapsing inflammatory disorders of the digestive tract that cause symptoms like diarrhoea, bleeding, and abdominal pain. Because these conditions are systemic, people with IBD frequently have extraintestinal symptoms (EIMs) like arthritis, aphathous stomatitis (AS), and primary sclerosing cholangitis (PSC).Between 25% and nearly 50% of paediatric IBD patients had at least one EIM at the time of diagnosis, based on the scant paediatric data that is currently available,sometimes the term "EIMs" is used to refer to conditions other than the more common ones, such as peripheral neuropathy (PN), pyoderma gangrenosum (PG), arthritis, and growth failure and anaemia. One of the neurological problems that is most commonly mentioned is peripheral polyneuropathy (PN). Numerous PN phenotypes in IBD patients have been documented. In patients with CD who have received metronidazole treatment, paresthesias and an elevation in the threshold for temperature detection are prevalent (21-39%), but they are also observed in patients who have not taken this medication (19%). These findings may indicate early PN

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