The study investigates the factors influencing patient-centered pharmaceutical care in India, emphasizing the impact of medication availability, affordability, and prescriber attitudes on patient health outcomes. A Structural Equation Modeling (SEM) approach was utilized to analyze the relationships between direct and indirect variables. The study examined various constructs, such as therapeutic effectiveness, cost-effectiveness, safety, and prescriber satisfaction, to understand their influence on patient factors and health outcomes. The SEM method revealed that medication availability and affordability significantly affect patient health outcomes. Additionally, prescriber attitudes were found to have a substantial impact on patient adherence to treatment regimens, with satisfaction with efficacy being particularly influential. The findings highlight the importance of improving medication access and affordability to enhance patient-centered care. The study also emphasizes the crucial role of prescriber attitudes in the healthcare delivery process. While the research supports targeted policy interventions, it acknowledges the need for further exploration of systemic barriers and comprehensive policy development. The study concludes that policy reforms focusing on medication availability and affordability, combined with prescriber education, are essential for optimizing patient-centered pharmaceutical care. The insights provided by this research contribute to the ongoing discussion on healthcare improvement and serve as a foundation for future policy-making efforts.