Leucomeris spectabilis is a medicinal plant widely known for its traditional use in various folk remedies. The present study was carried out to investigate morphological, microscopical and phytochemical screening of Leaves of Leucomeris spectabilis, aimed at unraveling its therapeutic potential and validating its traditional medicinal claims. In the microscopical studies, leaves showed the presence of epidermis at the upper surface. The epidermis on the outside is covered with thick cuticle. It is differentiated into the palisade parenchyma composed of tall compactly placed cells and the spongy parenchyma comprising oval or round loosely-arranged cells with inter cellular spaces. The vascular bundles which are the conducting tissues called xylem and phloem present and are conjoint and closed. Ash value, extractive value, foreign organic matter and moisture content was determined for quality standards of drugs. The powdered drugs were defatted with petroleum ether and successive extraction was performed. Phytochemical investigation shows the presence of Alkaloids, glycoside, flavonoids, phenolics, and saponins. Fluoresccence analysis were carried out under UV light. The result of the study could be useful for identification and preparation of monograph of the plant.