The term "toxicity" refers to the harmful effects of a drug on a living thing as a whole, including bacteria, plants, and animals, as well as the underlying structures of living things, such as cells (cytotoxicity), organs (organotoxicity), and livers (hepatotoxicity). The most prevalent manifestation of hepatotoxicity is liver dysfunction or damage brought on by taking too many medications or xenobiotics. Exogenous substances with clinical significance are known as hepatotoxicants like CCl4. The objectives ofPharmacological evaluation of hepatoprotective effect of leaves extract of Capsicum Chinense in CCl4 induced hepatotoxicity in Swiss albino mice.For hepatotoxicity studies, reduced dose of Capsicum Chinense (50mg/kg), (100mg/kg) was administered daily for 21days. Total bilirubin, Total protein, Albumin, Globulin, SGOT, SGPT, ALP and liver weight were estimated in serum. CCl4 dose (2ml/kg i.p) with olive oil in the ratio of 1:1 v/v twice in a week is given to mice for induced hepatotoxicity during 21 days studies. Induction of CCl4 dose (2ml/kg i.p) with olive oil in the ratio of 1:1 v/v increased the biochemical marker of Total bilirubin, SGOT, SGPT, ALP,and Total protein, albumin and globulin were decreased. The improving effect of Capsicum chinense in hepatotoxicity is investigated in this study.