The purpose of this study was to determine the effects of Ephedra viridis in normal and diabetic rats with antibacterial activities. Methods 40 male albino rats weighing between 200 and 240 gm were included in this study streptozotocin induced diabetic rats, randomly divided into 4 groups. Group 1 Normal control group,Group 2 Normal rats treated with Ephedra viridis,Group 3 Diabetic rats and Group 4 Diabetic rats treated with Ephedra viridis.. These groups tested for oral glucose tolerance test, HbA1C and lipids profile. The Results were significant in the group 4 for oral glucose tolerance test and HbA1C also showed significant difference in lipids profile. Also Antibacterial Activities showed inhibited both Gram negative and Gram-positive bacteria. Conclusion the Ephedra viridis showed significant effect in diabetic hyperlipidemia rats and antibacterial activities