Plant secondary metabolites emerged as the promising approach to control pests in crop fields towards sustainable agriculture. As the uncontrolled use of synthetic pesticides to control pests causes several side effects, the herbal-derived natural pesticide attracts the scientific communities to develop potent pesticides to replace commercial synthetic pest control agents. In line, the present research work was carried out to evaluate plant species viz., Heliotropium indicum L., Portulaca oleracea L., Blumea lacera L., Physalis angulata L., Achyranthes aspera L., and Salvia plebeia R. Br. were collected from Bilaspur district, for their pesticidal action against some bacteria and fungi including Escherichia coli, Staphylococcus aureus, Aspergillus flavus, and Alternaria solani. The result revealed that the maximum antibacterial action of 20.5 ±0.22 ZoI (in mm) against E. coli was observed with Methanol (100%) extract of P. oleracea L. whereas the maximum antifungal action of 17.2 ±0.18 ZoI (in mm) was accomplished with ethanol (100%) extract of A. aspera L. against A. flavus. The potent pesticides could potentially be used in sustainable agriculture practices to control pests and increase crop yield and certain pharmaceutical applications.