Phytochemicals are secondary metabolites found in plants that have medicinal and other useful uses. We discuss the effects on the gut microbiota and the phytochemistry and pharmacological possibilities of lemongrass (Cymbopogon) in this review. The anti-diabetic and antioxidant properties of lemongrass are well-known. As a result, it finds extensive application in the cosmetics, pharmaceutical, food, and feed industries. Geraniol, alkaloids, terpenoids, and phenolic metabolites (such as phenolic acids, flavonoids, stilbenes, and lignans) are powerful bioactive components found in lemongrass. There is no more valuable therapeutic herb than lemongrass. In addition, the phytochemicals included in lemongrass have the ability to promote health by restoring harmony to the microbiome. Because it does not produce any harmful byproducts or residue, lemongrass is ideal for use as an ingredient in industrial food and feed. Optimized nutrient absorption in the gastrointestinal system is enhanced by modulating the gut ecology using lemongrass powder and essential oils, which provide anti-microbial, anti-inflammatory, and antioxidant reactions. In this review, we will go deeper into the phytochemical, pharmacological, and medicinal properties of lemon grass.