Pilomatrixoma is a slow growing benign tumour which is most commonly misdiagnosed preoperatively as sebaceous cyst. It is a subcutaneous tumour emerging from the outer root sheath of hair follicles. We report a case series of pilomatrixoma presenting in Saveetha medical college and hospital. METHODS: The medical records of 10 patients presented with skin swelling from a single centre from April 2022 to April 2023 were retrospectively reviewed. RESULTS: There were a total of 10 tumours from 10 patients. The mean age at excision was 28± 5.6 years. Primary sites of occurrence include head and neck region (48.14%). No familial predominance noted. In most of the cases, a differential diagnosis of sebaceous cyst was made and final diagnosis of pilomatrixoma was confirmed by histopathological analysis.