The liver is an important organ with many functions needed for overall wellness, infections, and illnesses. Hepatoprotective effects serve as an important role in maintaining the liver from harm and helping its regeneration.The objectives include performing a comprehensive literature analysis in order to improve the efficiency and mechanisms of action of natural medicines in hepatoprotection.These medicines shows multiple functions including antioxidant, anti-inflammatory, and detoxifying qualities which together protects the liver from injury and helps in its recovery.Key natural substances such as curcumin, silymarin, omega-3 fatty acids, N-acetylcysteine, and vitamin E are highlighted for their extraordinary hepatoprotective benefits. These substances works through different channels, including antioxidative processes, regulation of inflammatory responses, and acceleration of liver cell regeneration.Despite advances in traditional medicine limitations and adverse effects associated with pharmacological treatments indicates the need for studying other approaches. Phytochemicals produced from plants shows hepatoprotective properties with other therapeutic advantages.