Millions of people worldwide suffer from psoriasis, a chronic inflammatory skin condition characterised by inflammation, scaly plaques, erythema, and hyperproliferation of keratinocytes. Currently, no specific treatment is available for psoriasis. The objective of this study is to formulate and assess the efficacy of polyherbal formulations for the treatment of psoriasis. Herbal extracts including boswellic acid, curcumin, and glycyrrhizin were integrated into a microemulsion gel formulation aimed at alleviating symptoms of psoriasis. Similarly, a formulation comprising Azadirachtin, Berberis aristata, and Coleus forskohlii was developed to target inflammatory skin conditions. The present study employed pseudoternary phase diagrams to aid in the selection of microemulsion regions for formulations utilizing varying Smix ratios. Among these formulations, numbers 3 and 4 exhibited notably enhanced stability when compared to formulations 1 and 2. Viscosity assessments unveiled thixotropic behavior within both BCG-Microemulsion and ABC-Microemulsion gels. In vitro drug release investigations demonstrated sustained release profiles for Azadirachtin, Berberine, and Forskolin, with Azadirachtin exhibiting a faster release rate. Additionally, Boswellic acid, Curcumin, and Glycyrrhizin showcased sustained release patterns, with Boswellic acid demonstrating a faster release rate compared to Curcumin and Glycyrrhizin. The present study has centered on the formulation of polyherbal remedies aimed at addressing psoriasis and inflammatory skin conditions. These formulations incorporate a combination of herbs including boswellic acid, curcumin, and glycyrrhizin, alongside Azadirachtin, Berberis aristata, and Coleus forskohlii. Encapsulated within a microemulsion gel matrix, these formulations exhibit promising potential for the management of psoriasis and related inflammatory skin disorders.