Since time immemorial, various defense mechanisms have been employed to combat several infectious diseases, in animals as well as in humans; however, from the commencement of the nineteenth century, vaccines were created and utilized majorly. The utilization of vaccines derived from plants is an evolving biotechnological tool that promises limitless potential in fighting viral, bacterial, and fungal diseases. The development of transgenic plants involves the incorporation of a desired antigen of pathogens into the selected host plant by a chosen genetic transformation method.Potatoesare a cardinal candidate to vehicle green factory vaccines; as they can be stored easily for longer period, they are grown widely – are people’s fourth food choice globally, with impeccable nutritional benefits: rich in vitamin C and Zinc, hence they have significantly higher potential to be impactful in disease control,in mostlow resource settings of Sub-Saharan Africa, due to their ease mode of culturing. Potatoes have monoclonal propagation, and they form a pentameric doughnut-like structure with the non-toxic part of subunit proteins, reducing the chances of horizontal gene transfer to wild types.This review article stipulates the notable benefits of plant-derived edible vaccines against the conventional oral vaccines.