ISSN : 2663-2187

Poverty in the Midst of Plenty – A Case of Leukocyte Adhesion Defect

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Dr. Saraladevi Manimaran, Dr. Hariharasudhan Thiyagarajan, Dr. Sundari Subramanian
» doi: 10.33472/AFJBS.6.6.2024.7407-7412

Abstract

An autosomal recessive inheritance pattern characterizes LAD I, a genetic condition. It is characterized by a CD18 expression deficiency, which leads to major deficits in the ability of white blood cells to migrate and respond to chemical signals. From a clinical perspective, this condition is characterised by repeatedinfections by bacteriaaffecting the mucosa and skin. Absence of pus formation results in impeded wound healing. This condition often begins with omphalitis, an infection of the umbilical cord. Timely identification and hematopoietic cell transplantation (HCT) before serious infections occur are critical for a positive prognosis. Although LAD-1 cases present with hallmark feature of delayed separation of umbilical cord, We present a 35-day-old baby who had separation of umbilical cord at correct time but presented with a perinasal hypopigmented lesion and omphalitis, exhibiting delayed healing (POVERTY) despite a high WBC count (PLENTY).

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