The purpose of pre-formulation is to ensure that a pharmaceutical dosage form will be created under the ideal conditions for material processing in order to achieve the performance and stability required. The main objective is to examine the possible luliconazole drug-excipient interactions and determine whether they are compatible with the formulation of transferosomal patches. For the transdermal medication delivery system to be stable and prosperous, it is essential to comprehend the following interactions like Solubility, Melting point, Partition coefficient, Spectroscopy and their compatibility studies such as Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Colorimetry (DSC) among the chosen excipients and these are just a few of the experimental studies done to define the physio-chemical properties of luliconazole. The results for the luliconazole's solubility, melting point, and partition coefficient were satisfactory. The FTIR spectra of luliconazole had distinctive spectra at 3112 cm-1 (CH aromatic stretching), 3041 cm-1 (C═C aromaticring), and 1326 cm-1(SH stretching), which were frequently present in all physical mixtures examined. There was no interaction in the drug's characteristic peak after mixing, the investigating spectra acquired a statement to that effect. On the basis of DSC results, luliconazole has been noted to be compatible with the selected excipients.