The rise of antibiotic-resistant infections has spurred interest in alternative antimicrobial therapies. Commelina benghalensis, rich in potassium, iron, calcium, ascorbic acid, and beta carotene, has long been used in traditional medicine. Combined with zinc oxide (ZnO) nanoparticles, known for their antibacterial properties, it presents a promising approach for advanced wound healing treatments. In this study, a gel formulation containing ZnO nanoparticles and Commelina benghalensis extract was developed and evaluated against common wound pathogens, including Pseudomonas aeruginosa and Staphylococcus aureus.Characterization using Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and scanning electron microscopy (SEM) confirmed the gel's composition and structure. The gel exhibited significant antibacterial activity, effectively inhibiting the growth of S. aureus and P. aeruginosa. Its controlled release properties allowed sustained antibiotic delivery for up to 96 hours, enhancing therapeutic efficacy. Furthermore, the addition of hydroxyethyl cellulose improved rheological properties, facilitating faster wound healing in animal models. Overall, the synergistic antibacterial action of Commelina benghalensis and ZnO nanoparticles, coupled with enhanced rheological characteristics and controlled drug release, highlights the gel's potential for managing wound infections and promoting healing.