Background: Dermatologic disorders frequently manifest oral lesions as part of their clinical spectrum. However, the prevalence and clinical characteristics of these lesions remain underexplored in dermatology patients, posing challenges for timely diagnosis and treatment. Objective: This cross-sectional study aims to determine the prevalence of oral lesions in patients with dermatologic disorders and analyze their clinical characteristics to improve diagnostic accuracy and therapeutic strategies. Methods: The study included 400 patients diagnosed with dermatologic disorders, including lichen planus, pemphigus vulgaris, psoriasis, and systemic lupus erythematosus, attending dermatology clinics across three tertiary care centers. Each patient underwent a thorough oral examination conducted by a dermatologist and an oral medicine specialist. Data on lesion type, location, duration, associated symptoms, and systemic disease correlation were documented. Statistical analysis was performed to determine the prevalence of oral lesions and their association with specific dermatologic conditions. Results: Oral lesions were identified in 62% of patients with dermatologic disorders, with the highest prevalence observed in those with pemphigus vulgaris (85%) and lichen planus (78%). Common lesion types included erosions (45%), plaques (30%), and ulcers (25%), predominantly located on the buccal mucosa and tongue. Burning sensation and pain were the most frequently reported symptoms. A significant association was found between the severity of dermatologic disease and the presence of oral lesions (p < 0.05). Conclusion: Oral lesions are prevalent in patients with dermatologic disorders and exhibit distinctive clinical features that can aid in early diagnosis and management. Routine oral examinations should be integrated into dermatologic care to improve patient outcomes. Further research is warranted to explore the pathophysiological mechanisms underlying these manifestations.