Dyslipidemia, a known risk factor for atherosclerosis, is frequent among both adults and children with chronic kidney disease (CKD). In addition, there is evidence to suggest that dyslipidemia contributes to the initiation and progression of CKD itself. Aim: To asses the frequency of dyslipidemia in children and adolscent with end stage renal disease (ESRD) on regular hemodialysis. Patients and Methods: Our study is a cross – sectional study included 61 patients with agesranging from 4-17 years who were diagnosed with end-stage renal disease (chronic kidney disease stage V with eGFR less than 15 ml/min/1.73m2 by modified Schwartz equation and on regular hemodialysis. Results: we found total cholesterol was high (>=200) in 18 (29.5 %) patients, was borderline (170 - 199) in 12 (19.7%) patients and was acceptable (<170) in 31 (50.8%) patients. The frequency of abnormally high levels of total serum cholesterol, triglycerides, and low-density were found to be 29.5%, 75.4% and 16.4% respectively. HDL ranged from 14.9 to 62.9 mg/dL with a mean value (± SD) of 37.59 (±8.68) mg/dL. 10(16.4 %) patients were acceptable (>45) ,11 (18%) patients were borderline (40 - 45), and 40 (65.6 %) patients were low (<40). LDL ranged from 54.8 to 166.7 mg/dL with a mean value (± SD) of 99.61 (±29.66) mg/dL. 39(63.9 %) patients were acceptable (<110) ,12 (19.7%) patients were borderline (110 – 129) and 10 (16.4 %) patients were high (>=130). VLDL ranged from 11.3 to 90.1mg/dL with a mean value (± SD) of 37.50 (±15.99) mg/dL. 21 (34.4%) patients were normal, and 40 (65.6%) patients were abnormal. Triglycerides, VLDL-C, and HDL levels were observed to be lower during maintenance hemodialysis. Conclusion: High percentage of examined children had high lipid profile (29.5 %) of the populations, The frequency of abnormally high levels of total serum cholesterol, triglycerides, and low-density were found to be 29.5%, 75.4% and 16.4% respectively. Triglycerides, VLDL-C, and HDL levels were observed to be lower during maintenance hemodialysis