Background: Self-medication refers to the practice of using drugs to treat disorders or symptoms that individuals have diagnosed themselves or the ongoing or occasional use of a prescribed drug for chronic or recurring diseases or symptoms. Engaging in improper self-administration of medication results in the irrational utilization of medications and the emergence of drug resistance.Objectives: The study aimed to assess the prevalence and pattern of antibiotic self‑medicationin Salem City Municipal Corporation, Tamilnadu. Materials and Methods: A community‑based cross‑sectional study was carried out in Salem City Municipal Corporation, Tamilnadu from May to July 2023. Data were collected from 370 adults by face‑to‑face interview using a Semi-structured questionnaire after obtaining consent. Data were entered in Excel and analysed using SPSS. Chi-Square was used to examine the association.