The purpose of this research was to analyse the factors of the mechanism in preventing and controlling the epidemic outbreaks in the community by the District Health Board. The sample consisted of 475 District Health Board members in Nakhon Si Thammarat, Thailand, using a simple random sampling method. The research instrument used in collecting the data was the questionnaires based on the components of the DHB's working guidelines, known as "UCCARE". The level of measurement was the ratio scale, and Cronbach's alpha coefficient was 0.936. In addition, descriptive statistics and confirmatory factor analysis were conducted. There were six components in the Confirmatory Factor Analysis and 32 observed variables. The research model agrees with the empirical data (2=1,610.79, 2/df<0.001, GFI=0.845, AGFI=0.842,CFI= 0.919, and RMSEA= 0.056). The variables that have been chosen to prevent and control epidemic outbreaks by the District Health Board were 11 observed variables as follows 1) two variables of Unity District Health Team, 2 ) two variables of Customer Focus,3.) two variables of Community Participation4) a variable of Appreciation5) two variables of Resource Sharing and Human Developmentand 6) two variables of Essential Care. Based on the findings, it was concluded that the components of the DHB's working guidelines, known as "UCCARE", could be applied as the mechanism for preventing and controlling the epidemic outbreaks in the community and could be used as the guidelines of development in preventing and controlling the epidemic outbreak which is corresponding to Thailand context.