Primary bone lymphoma (PBL) is a rare malignancy. Therefore, the present study aims to study clinicopathological profile at a tertiary cancer care centre in Southern India. The present retrospective study was conducted for two years, from January 2022 to December 2023. Data of all lymphoma patients was reviewed, and patients with PBL were selected. Patient characteristics, pathological features, imaging data, management protocols, and treatment outcomes were subsequently analyzed. 812 patients with lymphoma were registered during the two years, and five cases of PBL were identified. The distinct characteristics of these 5 cases are documented in the present report. The median age at presentation was 50 years (16-65 years). Pain was the most common presenting symptom, whereas the pelvis was the most commonly affected site (3 of 5 cases). The most common histological subtype was diffuse large B cell lymphoma (DLBCL), found in 3 of the five patients. Standard Chemotherapy protocols were started per the histology, and patients were followed. To conclude, since PBL is rare, it is frequently associated with non-specific clinical signs and, therefore, can be missed. Chemotherapy is the preferred treatment of choice. Of all the primary bone malignancies, PBL has the most optimal outcomes.