An extensive review of tuberculosis(TB) treatment examines the difficulties in using regular DOTS therapy, particularly when dealing with drug-resistant strains of the disease(MDR-TB and XDR-TB). Polypharmacology's importance in tackling these issues is emphasised in theintroduction. Emphasis on dual inhibitors against fatty acid biosynthesis (which target the enzymes FabG4 and HtdX), dual targeting of Protein Tyrosine Phosphatase B and GroEL/ES chaperonin, and CTP and CoA biosynthesis suppression (which targets PyrG and PanK concurrently) (disrupting protein homeostasis, granuloma formation, and intracellular survival). An intelligent approach to improved medication delivery is shown by the combination of isoniazid and rifampicin encapsulated in liposome’s. The review highlights the critical role that multi-targeted medications play in resolving tuberculosis issues. It also highlights the importance of further research and the possibility of reduced drug resistance, shorter treatment durations, and enhanced efficacy. All things considered, the information supplied provides a thorough and organised investigation of multi-targeted medications for the treatment of tuberculosis, skilfully merging scientific understanding with real-world uses.