Independent of race or social class, Parkinson’s disease (PD) affects between 15-25% of old people over the age of 60 and 4% of those over the age of 80. It is the second most prevalent neurogenerative illness in the elderly population. The brain area of the substantianigra, where dopamine (DA) is synthesized, is where Parkinson diseases brought on by the necrosis of dopaminergic neurons, which decrease the amount of dopamine in the synaptic cleft. Dopamine degradation by the Monoamine oxidise B (MAO_B) promopte4s glutamate build up and oxidative stress with the generation of free radicals, which result in excitotoxicity. The diagnosis of PD is determined by examining the motor symptoms because there is no laboratory test, biomarkers, or imaging investigation anti-cholinergic, dopaminergic agonist. There is known cure for the disease, these medication help patients live longer and function more normally.