Creating positive working environment with low or no cynicism feelings as well as eradicating counterproductive behaviors in workplace are the keys to organizational growth in the contemporary healthcare.Aim: investigate relationship between organizational cynicism and counterproductive work behavior among nurses. Subjects and Method: A descriptive correlational design was used to conduct this study. Setting: The study was conducted at Zagazig University Hospitals. Subjects: Stratified random sample was selected from nurses working at the above mentioned setting (n= 375). Tools: Two tools were used to collect these data, organizational cynicism scale and counterproductive work behavior scale. Results: (35.7%) of studied nurses had a moderate perception level of organizational cynicism. While, (81.1%)of them had a low perception level of counterproductive work behavior. Conclusion: there are highly statistically significant positive correlation between organizational cynicism and counterproductive behavior. Recommendations: Promoting a culture of trust among nurses by building an atmosphere of confidence, adopting the fair practices like operating in an open and honest atmosphere, emphasizing on a conflict-free environment, and fairness feeling among all of the staff.