Dexamethasone has been used as an medical aid in third molar surgery to reduce inflammation, trismus and pain. Dexamethasone is a high potent drug helping in the pain pathway. Dexamethasone is responsible for inhibiting the release of inflammatory mediators in the inflammation process to improve patient quality of life after surgical intervention. There are several available routes of administering dexamethasone. This article will help determine the suggested routes of administration, dosage, parameters, and dexamethasone timing for third molar surgeries.