It is common for solubility, a critical feature that governs the bioavailability and therapeutic efficiency of pharmacological compounds, to be a barrier to the creation of new drugs. As a result of their low solubility, pharmaceutical researchers have a great deal of difficulty when attempting to develop medications that are both more soluble and more sustained (BCS class II). There are issues with the solubility of medications that fall within BCS Class II and Class IV. When it comes to the world of pharmaceutical research, solubility enhancement is of great significance because its primary objective is to improve the solubility and bioavailability of medications that have a poor solubility by increasing their solubility. Because of their propensity to exhibit inadequate absorption, bioavailability, and therapeutic efficacy, medicines that are poorly soluble present a significant problem in the process of drug development. There are a few different approaches that may be taken in order to improve the bioavailability as well as the solubility of drugs that are already poorly soluble. In this review, we will be discussing two of the most essential techniques, which are the Liquisolid technique and the Self Emulsifying Drug Delivery System (SEDDS).