Incremental Sheet Metal Forming (ISMF) has emerged as a versatile and innovative method for deforming sheet metal, particularly advantageous for small batch production and rapid prototyping. This paper explores the application of ISMF in the manufacturing of custom-made biomedical implants, emphasizing its potential to revolutionize this field. Unlike traditional manufacturing processes that rely on expensive molds and complex setups, ISMF utilizes simple tools and fixtures, making it a cost-effective solution for producing intricate, asymmetrical components. This method is especially beneficial in the medical industry, where the demand for personalized implants is growing. The study delves into the specifics of Single Point Incremental Forming (SPIF), a subset of ISMF, which maintains the material's crystal structure while enabling precise deformation. Given the biocompatibility concerns with conventional Ti-6Al-4V alloys, which release toxic vanadium and aluminum ions, this research highlights alternative materials and methodologies to enhance safety and performance. Experimental results and finite element simulations demonstrate the improved forming limits and deformation capabilities of ISMF compared to traditional methods. The findings underscore ISMF's ability to produce complex shapes without the need for specialized molds, significantly reducing manufacturing costs and time. This paper also discusses the technological advancements in tool path generation and numerical simulations that have propelled ISMF to the forefront of rapid prototyping technologies. By showcasing successful applications in creating dental and orthopedic implants, this research confirms ISMF's transformative impact on biomedical manufacturing, paving the way for more efficient, customized, and patient-specific medical solutions