Background: Rhabdomyolysis is a serious condition characterized by skeletal muscle breakdown leading to the release of intracellular contents, including myoglobin, into the bloodstream, often resulting in acute kidney injury (AKI). This study aims to investigate the clinical characteristics, etiologies, and management approaches for rhabdomyolysis, with a focus on the prognosis and treatment outcomes. Methods: This retrospective observational study was conducted at Saveetha Medical College's Department of Medicine. It involved 30 patients with AKI secondary to rhabdomyolysis, confirmed through elevated serum CPK levels. Data on demographics, etiology, clinical presentation, and treatment were analyzed. Results: The study predominantly involved young to middle-aged males, reflecting specific occupational or lifestyle risk factors. The most common etiologies were physical trauma and AKI with hypokalemia. Clinical data indicated prevalent renal impairment and muscle damage, with varying levels of urea, creatinine, CPK, and electrolytes. The qSOFA score distribution and ICU stay durations indicated varied patient severity, with most requiring short ICU stays. Hemodialysis was more commonly employed over conservative fluid management. Correlation analysis showed significant associations between certain biochemical markers, like potassium and CPK, and the duration of hospital stays. Conclusion: Our findings highlight the need for early detection and tailored management strategies for rhabdomyolysis, given its varied presentations and severe potential outcomes. The reliance on hemodialysis points to the severity of renal complications. Future research should focus on larger, multicenter studies to explore diverse demographics, and long-term outcomes, and compare treatment modalities.