Sepsis, a complex and life-threatening condition, remains a leading cause of morbidity and mortality in emergency department (ED) settings. The early identification of risk factors for mortality in septic patients is crucial for improving patient outcomes. This study aims to identify these risk factors and to emphasize the impact of anesthesia management in sepsis care. A case-control study was conducted on septic patients presenting to the ED, comparing those who died with those who survived. Factors such as age, comorbidities, laboratory values, and anesthesia management were evaluated for their association with mortality. Statistically significant results revealed that advanced age, presence of cardiovascular disease, delayed intubation, and inappropriate anesthetic management were associated with higher mortality. Notably, early intubation and appropriate anesthetic interventions, such as careful titration of sedatives and analgesics, were linked to improved survival outcomes. This study introduces a novel perspective by incorporating anesthesia-related factors into the analysis of sepsis mortality, highlighting the crucial role of anesthesia in early resuscitation and management. The results suggest that optimizing anesthesia management in septic patients can significantly reduce mortality rates in the ED setting. This research fills an important gap by integrating anesthetic considerations into sepsis care, providing a foundation for future studies aimed at improving clinical outcomes.