One of the most promising approaches to assessing genetic predisposition to respiratory diseases is to identify their association with certain candidate genes. Studying the relationship For correspondence Zainitdin S. Kamalov – MD, PhD, Prof., Head of Lab., Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan, 100060, Tashkent https://orcid.org/0000-0001-6551-3155 Kamalov Zainitdin / Afr.J.Bio.Sc. 6(Si2) (2024) Page 3508 of 9 between the polymorphism of these genes and the production of cytokines will make it possible to predict the risk of developing pathology, and the nature and severity of its course. Purpose of the study. To study the features of polymorphism of the cytokine genes IL-4 IL17, and TNF-α in newborns and children in the first year of life with community-acquired pneumonia.