The ethanol extract of Sauromatum guttatum and Leonotis nepetaefolia isolated from it were evaluated for hepatoprotective activity against Rifampicin, Ethanol, Paracetamol and carbon tetrachloride induced toxicity in Wistar rats. The parameters studied were estimation of liver function serum markers such as Serumglutamic Pyruvate transaminase, serum Glutamic Oxaloacetic Transaminase and Alkaline phosphatase activities. The extract of Sauromatum guttatum showed moresignificant hepatoprotective activity than Leonotis nepetaefolia extract. The histological profile of the liver tissue of the root extract of Sauromatum guttatum treated animal showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration as similar to the controls. The results when compared with thestandard drug silymarin, revealed that the hepatoprotective activity of the constituent extract of Sauromatum guttatum issignificant assimilar to the standarddrug