The main objective of the current paper is to design a method for the simultaneous determination of paracetamol and caffeine in tablets that are readily available in the local market. We have used the Agilent chromatographic system fitted with a C-18 column for the separation. A mobile phase of methanol–water with composition (40:60 v/v) is used with the flow rate of 1.0 ml min−1. The detection of the peaks occurs at the wavelength 243 nm. The separation of paracetamol and caffeine is achieved without using any buffers or costly chemicals with the mobile phase. The method is linear over the range of 1.0-6.0 mg/100ml with correlation coefficients of 0.9978 for paracetamol and linear over the range of 0.2-1.2 mg/100ml with a correlation coefficient of 0.996 for caffeine. The average retention time for paracetamol and caffeine is found to be 3.37 minutes and 4.67 minutes respectively. The limit of detection for paracetamol and caffeine is 0.273 mg/100ml and 0.0848 mg/100ml respectively. In contrast, the quantitation limit for the paracetamol and caffeine are respectively 0.829 mg/100ml and 0.257 mg/100ml. The precision is expressed as a coefficient of variation and found to be less than 2%. The mean recovery of both the paracetamol and caffeine in the tablet is found to be in the range of 99.6%- 96.0% and 116 %-120% respectively. The content of caffeine is found to be larger than the amount mentioned in the tablet. The proposed method in this paper can be useful in drug validation having two active ingredients i.e. paracetamol and caffeine.