The aim of the project is to develop a fast, simple, precise, and cost-efficient RP-HPLC method for measuring the amounts of Levosulpiride and Rabeprazole simultaneously in both pharmaceutical products and bulk samples. This technique has effectively achieved the separation of Levosulpiride and Rabeprazolebulk. The separation was performed using a Phenomenex C18 150 x 4.6 mm, 5m analytical column at a wavelength of 280 nm. The mobile phase consisted of a mixture of Potassium dihydrogen orthophosphate, acetonitrile, and water in a ratio of 30:55:15. The pH of the buffer was adjusted to 6.0. The separation was carried out in isocratic elution mode with a flow rate of 1.2 ml/min. Levosulpiride had a retention time of 3.852 minutes, whereas Rabeprazoleshowed a retention duration of 5.987 minutes. Quantitative analysis of Levosulpiride and Rabeprazole was achieved using PDA detection at 280 nm using a linear calibration curve. The concentration ranges of 10-50 µg/ml (with a correlation coefficient of 0.9997) and 10-50 µg/ml (with a correlation coefficient of 0.9999) were used for reliable quantification for Levosulpiride and Rabeprazole respectively. The limit of detection (LOD) for Levosulpiride was 0.2345 µg/ml, whereas the LOD for Rabeprazole was 0.2456 µg/ml. The proposed method is highly suitable for use in quality-control laboratories for the bulk and pharmaceutical quantitative analysis of pharmaceuticals, whether used individually or in combination. This technique is characterized by its simplicity and efficiency, while yet ensuring a high level of accuracy and precision.