ISSN : 2663-2187

Solubility Enhancement of Sunitinib by Solid Dispersion Technique

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Mr. Sandeep Mukati, Dr. Ravikant Gupta
ยป doi: 10.48047/AFJBS.6.10.2024.7133-7144

Abstract

To improve dissolution of poorly water-soluble drugs and thus enhancing their bioavailability, the dispersion of one or more active pharmaceutical ingredient in a carrier at solid state is used. This process is known as solid dispersion. It has engrossed significant interest as an efficient means of improving the dissolution rate. It happens due to dispersions of poorly water-soluble drugs with water-soluble carriers. The one of the most challenging aspects in formulation development is solubility behaviour of drugs. The number of poor water soluble compounds has radically increased. Compared to conventional formulations such as tablets or capsules, solid dispersions prepared by various methods can be used which have many benefits over the above conventional dosage form. it follows First order kinetic drug release models.

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