Parkinson disease is a progressive disorder that impacts the central nervous system and the component that are controlled by nerves. Major pathological hallmark of Parkinsonism is the presence of anomalous aggregates of α-Synuclein protein. Several experimental and pathological studies explain the other key involvement in PD pathogenesis like; loss of dopaminergic neurons is mid brain, Chronic microglial and astrocyte’s activation, mitochondrial dysfunction, brain inflammation and oxidative stress. Parkinsonism indicates the several motor and non-motor symptoms like bradykinesia (slowness and stiffness in movement), tremor and resting tremor. There is no known permanent treatment of Parkinson disease, yet certain drugs are effective on symptoms. Blue green algae such as spirulina is a unicellular species and economically distributed as nutritive food supplements. Spirulina is one the influential source of natural nutrient and many experimental studies informed about the antioxidant and anti-inflammatory properties of spirulina in parkinsonism. Spirulina contain multiple nutrients like vitamins, protein and essential fatty acid. Phycocyanin; colour pigment protein of spirulina algae which is playing a crucial role in brain inflammation and certain PD related pathogenesis oxidative stress, microglial cell activation, cytotoxicity