Women’s periodontal health is significantly influenced by steroid sex hormones, which impact various organ systems. Estrogen primarily causes changes in blood vessels, while progesterone promotes the production of inflammatory mediators. Additionally, certain microorganisms in the human mouth produce enzymes necessary for steroid synthesis and metabolism. During puberty, ovulation, and pregnancy, increased levels of sex steroid hormones in women lead to heightened gingival inflammation, characterized by gingival enlargement, increased bleeding, crevicular fluid flow, and microbial shifts. Effective clinical periodontal therapy requires an understanding of the clinician's role in the overall health and well-being of female patients. Dentists must recognize that treating localized infections can affect other bodily systems, as well as the foetus or breastfed infant. The unique periodontal and systemic issues faced by female patients can necessitate adjustments in conventional therapy, highlighting the crucial role dentists play in their care.