Larvae of multivoltine breed silk worm Bombyx mori L. (Nistari) was studied in both favorable and unfavorable rearing seasons after Grasserie disease caused by Bombyx mori Nuclearpolyherosis Virus (BmNPV) using various disinfectants. Chemical treatments using various complex mixtures were administered to minimize the extent of damage, which in turn may help the stakeholders to step ahead on the progression of sustainable sericulture by avoiding huge crop loss.